Published in Clinical Cancer Research. Feb. 2009; 15; 821
This research was to assess chemotherapeutic effect of grape seed extract proantho-cyanidins (OPCs) on human non-small cell lung cancer (NSCLC) cells in vitro and in vivo using a tumor xenograft model. At the cellular level, this was about how human NSCLC cell lines in terms of cellular proliferation were affected by OPC.
The OPC grape seed extract was incorporated into AIN76A control diet and was fed to nude mice bearing tumor xenografts (A549 and H1299). The effect of the OPC grape seed extract was evaluated using 3 different biomarkers, including those of cell proliferation and angiogenesis. The effects of OPC on insulin-like growth factor binding protein-3 were studied using immunohistochemical detection, ELISA, and Western blotting.
The cellular proliferation of NSCLC cells was significantly inhibited by the OPC grape seed extract in the cell culture. A dose-dependent inhibition of the growth of NSCLC (A549 and H1299) tumor xenografts in athymic nude mice (25-76%; P < 0.05-0.001) was observed when the OPC grape seed extract in 3 doses of 0.1%, 0.2%, and 0.5%, w/w was supplemented in an AIN76A control diet. The OPC grape seed extract up-regulated the levels of insulin-like growth factor binding protein-3 in the tumor microenvironment and plasma. The OPC grape seed extract also exerted 3 other effects, including antiproliferative, antiangiogenic, and proapoptotic effects. Consequently, the OPC grape seed extract exhibited the growth-inhibitory effect on the NSCLC xenograft tumors.
This was the first study showing that the growth of human NSCLC tumor xenografts was inhibited by OPC grape seed extract in athymic nude mice model. Therefore, the OPC grape seed extract may have potential benefits in prevention of lung cancer in humans, and further studies including clinical trials are needed.
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